In smokers, lung cancer is different than in non-smokers

Lung cancer in non-smokers is a different disease than in smokers, and probably speaks differently to certain treatments. The shows the so far most comprehensive study on the biology of lung cancer in non-smokers in the prestigious journal "Cell". This could open up new ways to separate patients with different tumor characteristics and to treat them with tailor-made therapies.

In Taiwan, the lung cancer rate in non-smokers is particularly high. Scientists from Taiwan and the United Kingdom have been found in tumor samples from 103 patients, most of which are non-Smoking goods, a number of genetic changes, the signs of genetic damage by certain cancer-causing substances in the environment.

In particular, in young women, genetic changes were detected, of which one knows that they lead to a particularly aggressive lung cancer. Dr. Jyoti Choudhary, team leader for functional proteomics at the Institute of Cancer Research in London, said: "Some of the lung tumors in the early stage, molecular characteristics, which are similar to those that typically occur in diseases in late-stage had. This could help us diagnose patients with aggressive disease more accurately, and the treatment strategies to adapt."

Lung cancer is also Mämen and women are different

The study showed that in smokers and non-smokers as well as men and women have different genetic changes. Choudhary explained: "We have found in non-smokers between women and men have different patterns of genetic error, suggesting that a woman who has never smoked, responsive is likely to be different to the treatment than a male smoker."

Further, the Team identified 65 proteins that were present in the lung tumors are particularly active. This could serve as a Marker for the early detection or in the case of the decision on the use of certain drugs in the therapy of help. Although in the study, people from Taiwan were examined, the researchers believe that many of the results are on British patients-transferable. They plan to confirm their findings by larger studies outside of Asia.

ZOU